TABLE 2

Cph2-regulated genes from RNA-seq that overlap genes regulated by hypoxia and Upc2

ConditionSystematic nameGene nameDescriptionFold change, WT/cph2Mean log fold changea
WT, −O2/+O2WT/upc2, −O2
Cph2 + hypoxiaorf19.6882OSM1Putative flavoprotein subunit of fumarate reductase−4.7091.74
orf19.2608ADH5Putative alcohol dehydrogenase−4.6882.39
orf19.2023HGT7Putative glucose transporter−4.1330.90
orf19.2344ASR1Putative heat shock protein−4.0981.56
orf19.7284ASR2Gene regulated by cyclic AMP and by osmotic stress−3.9123.62
orf19.2241PST1Putative 1,4-benzoquinone reductase−3.6751.95
orf19.4044MUM2Protein similar to S. cerevisiae Mum2p−3.2640.97
orf19.3822SCS7Putative ceramide hydroxylase−3.2481.67
orf19.2803HEM13Coproporphyrinogen III oxidase−3.1872.48
orf19.1395Ortholog(s) has inorganic phosphate transmembrane transporter activity−3.0841.73
orf19.5158Protein with similarity to product of a human gene associated with colon cancer and to orf19.5158−3.0290.99
orf19.4631ERG251C-4 sterol methyl oxidase with a role in ergosterol biosynthesis−2.9471.21
orf19.3651PGK1Phosphoglycerate kinase, enzyme of glycolysis−2.8612.36
orf19.5437RHR2Glycerol 3-phosphatase−2.7362.85
orf19.6321PGA48Putative glycosylphosphatidylinositol-anchored, adhesin-like protein−2.6051.08
orf19.3707YHB1Nitric oxide dioxygenase, acts in nitric oxide scavenging/detoxification−2.604−1.61
orf19.6770ENT4Ortholog of Candida dubliniensis CD36, CD36_87190−2.5751.11
orf19.1862Possible stress protein−2.5693.30
orf19.1048IFD6Aldo-keto reductase family member−2.5603.27
orf19.7027Ortholog of C. parapsilosis CDC317, CPAR2_301430−2.5570.98
orf19.3997ADH1Alcohol dehydrogenase complements S. cerevisiae adh1 adh2 adh3 mutation; biofilm, fluconazole, and farnesol induced−2.48752.22
orf19.395ENO1Enolase, enzyme of glycolysis and gluconeogenesis−2.39122.55
orf19.5079CDR4Putative transporter of ATP binding cassette superfamily−2.35272.45
orf19.1802OFD1Putative termination and polyadenylation protein−2.29791.54
orf19.903GPM1Phosphoglycerate mutase−2.27052.55
orf19.3139Hap43p-repressed gene−2.00631.04
orf19.1034Hap43p-repressed gene−1.94171.60
orf19.6814TDH3NAD-linked glyceraldehyde-3-phosphate dehydrogenase−1.9182.90
orf19.3104YDC1Protein with Mob2p-dependent hyphal regulation−1.90121.18
orf19.5205Hap43p-repressed gene−1.84740.83
orf19.5801RNR21Ribonucleoside-diphosphate reductase−1.64511.06
orf19.339NDE1Putative NADH dehydrogenase1.74861−1.08
orf19.685YHM1Putative mitochondrial carrier protein1.85585−1.01
orf19.9Ortholog of C. parapsilosis CDC317, CPAR2_2042802.003520.53
orf19.6916Ortholog(s) has unfolded protein binding activity2.26845−1.02
orf19.6724FUM12Putative fumarate hydratase, enzyme of citric acid cycle2.30815−2.08
orf19.5806ALD5NAD-aldehyde dehydrogenase2.97536−2.30
orf19.183HIS3Imidazole glycerol-phosphate dehydratase3.32823−1.86
orf19.7112FRP2Putative ferric reductase4.107591.02
orf19.4773AOX2Alternative oxidase4.43443−2.22
orf19.4393CIT1Citrate synthase5.18316−2.10
Cph2 + Upc2 + hypoxiaorf19.4450.1Protein conserved among the fungal CTG clade−41.01−1.151.84
orf19.3548.1WH11Cytoplasmic protein expressed specifically in white phase yeast cells−3.5775.641.36
orf19.4943PSA2Mannose-1-phosphate guanyltransferase−2.9512.131.22
orf19.4530.1Biofilm- and planktonic growth-induced gene−2.49622.161.35
orf19.2770Ortholog of C. parapsilosis CDC317, CPAR2_500340−2.35851.081.48
orf19.4476Predicted ORF in Assemblies 19, 20 and 21−2.04980.781.76
orf19.4056BRG1DNA binding transcription factor involved in control of biofilm formation−1.91731.621.16
orf19.260SLD1Sphingolipid delta-8 desaturase−1.70961.94−1.10
orf19.4506LYS22Putative homocitrate synthase1.9834−0.991.39
orf19.5741ALS1Adhesin; ALS family of cell surface glycoproteins3.0932−1.030.93
  • a Data are from reference 30.