TABLE 1

Budding yeast HATs and HDACs

Catalytic subunitComplexActivitySubstratesReference(s)
Gcn5pSAGA and others (SLIK/SALSA, ADA, HAT-A2, HATB3.1)KATH3: K4, K9, K14, K18, K23Histone acetylation reviewed in 2, 9, 14, 147
H2B: K16
Rsc4p47, 48
Swi2p49
Spt7p, Ada3p, Sgf73p12
Ume6p148
Ifh1p43
Esa1pNuA4, Piccolo NuA4KATH2A: K5, K8Histone acetylation reviewed in 2, 9, 62, 63
H2B: K11, K16
H4: K5, K8, K12, K16, K20
Htz1: K3, K8, K10, K1435, 149
Esa1p50
Sip2p5
Pck1p: K19, K5145
Yng2p20
Cdc3p, Cdc10p, Cdc12p, Shs1p44
Rtt109pKATH3: K9, K27, K56
Rtt10951
Hat1pHat1p-Hat2pKATH2A: K8
H4: K5, K1260
Sas2pSASKATH4: K16, K20
Sas2p50
Sas3pNuA3KATH3: K14, K23150
Elp3pElongatorKATH3: K14151
H4: K8
Rpd3pRpd3(S), Rpd3(L)HDACH2A: K5ac, K8acHistone deacetylation reviewed in 2, 14, 67
H2B: K11ac, K16ac
H3: K9ac, K14ac, K18ac, K23ac
H4: K5ac, K8ac, K12ac
Swi4p6
Yng2p20
Rad53p152
Hda1pHDAHDACH2B: K16ac
H3: K9ac, K14ac, K18ac, K23ac
Htz1p: K14ac20
Hos1pHDACH4
Smc3p153
Hos2pSet3CHDACH3: K9ac, K14ac, K18ac, K23ac
H4: K5ac, K8ac, K12ac, K16ac, K20ac
Hos3pHDACH3, H4, H2A, H2B154
Sir2pSir, RENTHDACH4: K16ac, K20ac155
Ifh1p43
Pck1p5
Hst1pSum1p/Rfm1p/Hst1pHDACH4: K16ac, K20ac155
Set3C
Hst2pHDAC155
Hst3p/Hst4pHDACH3: K56ac155