Table 2

Adhesins in non-Candida human pathogenic fungi

FungusAdhesin (accession no.)Structural propertiesaSubstrate and/or functional propertiesReference(s)
Aspergillus fumigatusRodA (EAL91643.1)159 aa, GPI?Hydrophobin; adhesion to collagen and bovine serum albumin93, 94
CalA (EAL92612.1)177 aaBinding to laminin and murine lung cells95
CspA (XP_754717.1)430 aa, repeats, GPIConidial adhesion to ECM of human alveolar epithelial cells; expression during conidial germination96
Cryptococcus neoformansCfl1 (AFR92926.1)309 aaCell-cell adhesion (flocculation); biofilm formation; hypha specific97
Coccidioides immitisSOWgp (AAL09436.1)422 aa, repeats, GPIBinding to laminin, fibronectin, and collagen IV; role in virulence; spherule outer wall protein98
Blastomyces dermatitidisBAD1/WI-1 (AAA91036.1)1,146 aa, repeats, epidermal growth factor-like cysteine-rich consensus sequence at C terminusAdhesion to yeast chitin and macrophages; modulation of TNF-α production by phagocytes99, 100
  • a All proteins have signal peptides for secretion. GPI, glycosylphosphatidylinositol-anchoring signal peptide. The GPI-anchor signal prediction in RodA is controversial as it includes one of the eight cysteines, which are believed to be crucial for correct folding of this amphipathic protein.