Table 1

List of Msl1-regulated gene having known functions

H99 locus tagFold changeaGene (S. cerevisiae gene)bFunctional description
CNAG_04379−2.843(VPS55)Late endosomal protein involved in late-endosome-to-vacuole trafficking
CNAG_03297−2.344MSL1Msi1-like protein 1 in C. neoformans
CNAG_03143−1.107HSP12Small heat shock protein orthologous to yeast Hsp12 in C. neoformans; regulated by the cAMP and HOG pathways and involved in antifungal drug resistance
CNAG_05144−0.985CAN2Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in nonclassical protein export pathway
CNAG_01588−0.789(PMP3)Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under conditions of high-salt concn or low temp
CNAG_04879−0.766(GDB1)Glycogen-debranching enzyme containing glucanotransferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation
CNAG_07368−0.733(YVC1)Vacuolar cation channel; mediates release of Ca2+ from the vacuole in response to hyperosmotic shock
CNAG_01446−0.727HSP122Small heat shock protein paralogous to C. neoformans Hsp12; regulated by the cAMP and HOG pathways and involved in antifungal drug resistance
CNAG_04381−0.652(SSL1)Component of the core form of RNA polymerase transcription factor TFIIH
CNAG_07808−0.594(AGX1)Alanine:glyoxylate aminotransferase; catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast
CNAG_037720.892(SNF3)Plasma membrane glucose sensor that regulates glucose transport
CNAG_033470.922(HSP78)Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins
  • a Fold change indicates the log2(msl1Δ/WT) change. Genes having expression level changes of more than 1.5-fold are listed.

  • b Gene names in parentheses indicate S. cerevisiae gene names based on BLAST search results.