Table 1

Cell cycle regulatory proteins in Trypanosoma brucei

Cell cycle stage regulatedGene product(s)Human homolog(s)FunctionReference(s)
G1/S transitionCYC2NoneG1 cyclin43, 70
CRK1Not knownG1 CDK109, 110
CRK2Not knownG1 CDK109, 110
DNA replication and S-phase progressionOrc1/Cdc6ORC1Origin recognition complex35
Orc1bNoneOrigin recognition complex20
Orc4ORC4Origin recognition complex107
Tb3120NoneOrigin recognition complex107
Tb7980NoneOrigin recognition complex107
Mcm2-7Mcm2-7CMG component20
Cdc45Cdc45CMG component20
GINS (Sld5, Psf1, Psf2, Psf3)GINS (Sld5, Psf1, Psf2, Psf3)CMG component20
TLK1TLK1, TLK2Toulsed-like kinase64
Asf1A, Asf1BAsf1A, Asf1BHistone H3 chaperone64
G2/M transitionCYC6Cyclin BMitotic cyclin42, 70
CYC8Cyclin BMitotic cyclin70
CRK3Cdk1Mitotic CDK109
CRK9NoneMitotic CDK37
MitosisAUK1, CPC1, CPC2Aurora B, none, noneChromosomal passengers65, 71, 108
TLK1TLK1, TLK2Toulsed-like kinase64
KIN-ANoneDivergent kinesin65
KIN-BNoneDivergent kinesin65
Kif13-1MCAKKinesin-1318, 118
APC1, Cdc27APC1, Cdc27Anaphase-promoting complex61
SMC3, SCC1SMC3, SCC1Cohesin11, 34
SeparaseSeparaseProtease11
NOP86NoneNucleolar protein14
CytokinesisAUK1, CPC1, CPC2AUK1, none, noneChromosomal passengers65, 71, 108
PLKPLK1Polo-like kinase44, 62
MOB1MOB1Unknown45
PK50, PK53NDR1Nuclear DBF-2-related kinase75
TRACKRACK1Rho kinase94
RHPRhoARhoA-like GTPase1
CFB2NoneF-box protein8
ARL2Arl2Small GTPase90
AIR9NoneMicrotubule-associated protein77
KAT80, KAT60p80 katanin, p60 kataninKatanin9
SPASpastinSpastin9