Table 2

Classes of genes that are upregulated during OPC infection

Response pathwayaRepresentative genesb
General stressDDR48, orf19.675, SOD5c
Alkaline pHCAT1, ECM331, GCA1, GNP1, IHD1c, PHR1c, PHR2, PRA1d, SCW4
Oxidative stressCAP1, CAT1, orf19.6816, TRR1d, TRX1d, SOD4
Nitrosative stressTRR1d, YHB1c, CAT1
Iron limitationALS2, ARO9, CAT1, CIT1, ECM331, orf19.409d, orf19.5282, orf19.670.2, orf19.675, PCK1c, PGA48, PHR2, RNR22, STF2, TRX1, UCF1, YHB1c
Zinc limitationCSH1, GCA1, GCA2, IFD6d, orf19.1534, PRA1d, ZRT1d, ZRT2d
HypoxiaECM331, orf19.2030, orf19.670.2, orf19.675, orf19.670.2, PCK1c
Hyphal and virulenceALS1d, ALS3c, ECE1c, FAV2, HWP1c, HYR1, IHD1c, orf19.670.2, PCK1c, SAP4c, SAP5c, SAP6c, TEC1, UME6
OtherADH1, ALS7, FBP1, GCN4, HGT6, KIP4, orf19.2125, orf19.3460, orf19.4174, orf19.4706, orf19.6329d, orf19.6578, PGA13, PGA17d, PGA25d, PGA34, PLB5, RCT1, SGA1, UGP1
  • a Response pathways, defined by in vitro studies, are pathways whose activation results in upregulation of the genes listed.

  • b The C. albicans genes listed were upregulated in OPC infection samples compared to in vitro growth in Spider medium at 37°C. Note that some genes are activated by multiple pathways and thus may be listed more than once.

  • c Gene identified as OPC-upregulated gene in prior studies.

  • d Gene trended toward upregulation but had a t test P value of <0.1 and >0.05. All other genes listed displayed significant upregulation, reflecting a t test P value of <0.05.