Table 2.

Known bradyzoite and tachyzoite developmentally regulated genes

Probe setGene IDGene nameProductAvg expressionaFold changeb
2dT4dB8dB21dB4dB vs 2dT8dB vs 2dT21dB vs 2dT21dB vs 4dB
Upregulated in bradyzoites versus tachyzoites
    55.m00009_atTGME49_059020BAG1Heat shock protein, bradyzoite antigen6.29.99.410.0291834
    583.m09133_atTGME49_114250BRP1Bradyzoite rhoptry protein5.
    23.m00149_s_atTGME49_007130SAG2YSurface antigen (SRS49A)
    641.m01562_atTGME49_120190SRS9Surface antigen (SRS16B)
    80.m00010_atTGME49_091040LDH2Lactate dehydrogenase
Downregulated in bradyzoites versus tachyzoites
    59.m00008_atTGME49_071050SAG2ASurface antigen (SRS34A, P22)
    44.m00010_atTGME49_033480SRS2Surface antigen (SRS29C, P35)
    44.m00009_atTGME49_033460SAG1Surface antigen (SRS29B, P30)
    44.m00006_atTGME49_032350LDH1Lactate dehydrogenase
  • a 4dB, 4-dpi bradyzoites; 8dB, 8-dpi bradyzoites; 21dB, 21-dpi bradyzoites; 2dB, 2-dpi tachyzoites. Average normalized glog-transformed expression values.

  • b Fold change calculated from glog mean expression values back-transformed to the original scale (see Materials and Methods) and shown only where values are significantly different (P < 0.05). —, fold change not significant.