Table 3.

Chemical sensitivity summary

Deleted geneSensitivitya
Cytochalasin ABenomylFK506SorbitolSodium chlorideFludioxoniltert-Butyl hydroperoxideMenadione
stk-10S
stk-23S
camk-4R
stk-16SSS
prk-10RS
mus-58S
prk-3S
div-4S
stk-47S
ckaS
stk-46S
gsk-3R
ime-2R
stk-54R
stk-22RR
ptk-2S
stk-30S
stk-5S
stk-38SSS
stk-9SSS
nim-1R
stk-17/fiS
apg-1SSSSS
stk-29S
stk-4SS
  • a Mutants were classified as sensitive (S) or resistant (R) relative to the wild type based on the percentage of growth in the presence of the chemical compared to growth in the absence of the chemical, as follows: percent growth = (colony radius with chemical)/(colony radius without chemical) × 100. See Materials and Methods for details. For all compounds, sensitivity was scored directly from the average growth rate, except for menadione, for which sensitivity was scored after the average growth rates were binned (see Table S1 in the supplemental material). Corroboration of findings was based on the version 5 annotation of the Broad Institute's Neurospora crassa database (www.broadinstitute.org/annotation/genome/neurospora/MultiHome.html).