Table 2.

Functional annotation of differentially expressed genes (P < 0.01) in ΔCAF1 parasites during asexual developmenta

Parasite stagebGO enrichment of upregulated genesGO enrichment of downregulated genes
ERNoneNone
LRChromosome organization and biogenesis; DNA replication; small GTPase-mediated signal transduction; entry into host cellPathogenesis (var); RNA splicing; translation
ETDNA replication; small GTPase-mediated signal transduction; entry into host cellPathogenesis (var genes)
LTNoneAntigenic variation (rifin); mRNA metabolic process; translation; protein transport; small GTPase-mediated signal transduction
ESNoneNone
LSNoneNone
  • a Based on gene ontology, biological process annotation using the MADIBA Web server (21).

  • b ER, early ring; LR, late ring; ET, early trophozoite; LT, late trophozoite; ES, early schizont; LS, late schizont.