Table 4.

Genes with differential expression in a upc2Δ strain whose promoters are bound by Upc2

Locus tagGeneDescriptionMean log fold changeaMean BRb
Downregulated genes
    Ergosterol biosynthesis
        orf19.391UPC2Transcriptional regulator of ergosterol biosynthetic genes−5.141.90
        orf19.922ERG11Lanosterol 14-alpha-demethylase−1.897.80
        orf19.1631ERG6Δ24-sterol C-methyltransferase−1.882.90
        orf19.406ERG1Squalene epoxidase−1.581.50
        orf19.6026ERG2C-8 sterol isomerase−1.461.80
        orf19.5178ERG5Putative C-22 sterol desaturase−1.453.95
        orf19.1591ERG10Acetyl coenzyme A acetyltransferase−1.111.15
        orf19.1598ERG24C-14 sterol reductase−0.741.65
    Multidrug transport
        orf19.5604MDR1Multidrug efflux pump of plasma membrane−1.273.95
    Miscellaneous
        orf19.2251AAH1Similar to serine/threonine dehydratases−1.801.60
        orf19.1996CHA1Uncharacterized−1.791.70
        orf19.6090NSR1Uncharacterized−1.711.70
        orf19.1691Uncharacterized−1.713.95
        orf19.1030FPR3Uncharacterized−1.581.60
        orf19.5010DIM1Similar to S. cerevisiae Dim1p−1.582.75
        orf19.3291HMT1Major type I protein arginine methyltransferases (PRMT)−1.521.65
        orf19.18IMH3IMP dehydrogenase−1.431.90
        orf19.2575Uncharacterized−1.251.95
        orf19.1901MCM3Uncharacterized−1.131.60
        orf19.657SAM2S-adenosylmethionine synthetase−1.042.25
        orf19.5066Uncharacterized−1.031.85
        orf19.496MSH1Uncharacterized−1.021.50
        orf19.6253RPS23ARibosomal protein−1.021.60
        orf19.2309.2RPL2BUncharacterized−0.971.70
        orf19.4889HOL2Predicted membrane transporter−0.9410.75
Upregulated genes
    orf19.2593BIO2Biotin synthase0.891.50
    orf19.6311Uncharacterized0.911.60
    orf19.251ThiJ/PfpI protein family1.021.50
    orf19.2699ABP1Protein similar to S. cerevisiae Abp1p1.031.70
    orf19.1789.1LYS1Mitochondrial homoisocitrate dehydrogenase1.061.60
    orf19.1307Uncharacterized1.071.50
    orf19.4833MLS1Malate synthase1.091.60
    orf19.1350Uncharacterized1.1618.50
    orf19.1267CAJ1Uncharacterized1.171.65
    orf19.7204Uncharacterized1.232.20
    orf19.4711Uncharacterized1.361.65
    orf19.3282BMT3β-Mannosyltransferase1.491.90
    orf19.6840Uncharacterized1.851.70
  • a Change in expression in a upc2Δ strain in hypoxia.

  • b BR, binding ratio (from reference 91).