Table 2.

Genes with differential expression in hypoxia, following ketoconazole treatment, and in a upc2Δ background

Locus tagGeneDescriptionLog fold change
HypoxiaKetoconazole treatmentupc2Δ background
Ergosterol synthesis pathway
    orf19.767ERG3C-5 sterol desaturase2.471.59−2.34
    orf19.922ERG11Lanosterol 14-alpha-demethylase1.491.14−1.89
CFEM family
    orf19.5636RBT5GPI-anchored cell wall protein involved in hemoglobin utilization2.771.40−2.17
    orf19.5635PGA7Hyphal surface antigen1.901.16−1.48
Iron metabolism
    orf19.5634FRP1Predicted ferric reductase3.392.53−1.97
    orf19.4215FET34Multicopper ferroxidase2.630.75−1.05
Galactose metabolism
    orf19.3675GAL7Galactose-1-phosphate uridyl transferase−1.571.131.16
    orf19.3672GAL10UDP-glucose 4-epimerase−1.471.591.83
    orf19.3670GAL1Galactokinase−1.301.951.30
Miscellaneous
    orf19.1691Uncharacterized6.332.45−1.71
    orf19.3548.1WH11Cytoplasmic protein5.642.131.36
    orf19.2959.1Uncharacterized2.652.151.92
    orf19.251ThiJ/PfpI protein family2.221.011.02
    orf19.3932Uncharacterized2.091.802.40
    orf19.675Similar to cell wall proteins2.031.301.25
    orf19.260SLD1Sphingolipid Δ8 desaturase1.941.33−1.10
    orf19.7218RBE1Putative cell wall protein1.73−0.89−2.01
    orf19.5103Uncharacterized1.73−0.93−1.00
    orf19.6117Uncharacterized1.680.931.10
    orf19.4477CSH1Member of aldo-keto reductase family1.571.872.34
    orf19.4255ECM331GPI-anchored protein1.281.751.99
    orf19.6637Uncharacterized1.270.911.67
    orf19.6877Uncharacterized1.191.351.34
    orf19.2030Uncharacterized1.101.381.81
    orf19.6554Uncharacterized1.011.431.95
    orf19.4082DDR48Immunogenic stress-associated protein0.824.704.18
    orf19.999Uncharacterized0.791.081.08
    orf19.4476Uncharacterized0.781.921.76
    orf19.5125Uncharacterized0.671.381.59
    orf19.4506LYS22Homocitrate synthase−0.991.481.39
    orf19.4716GDH3NADP-glutamate dehydrogenase−1.391.002.36
    orf19.670.2Uncharacterized−3.121.321.30