Table 2.

Comparison of C. albicans gene expression during growth in the cecum and growth under laboratory conditions

Gene type and conditionNo. of genesNo. of genesP c No. of filtered upregulated genesdFiltered overlap (no. of genes)fFiltered P valued
Overlap expectedaOverlap observedbExpectedObserved
Upregulated genes
    Cecum408358
    Alkaline pHe24716494 × 10−1620412352 × 10−10
    Hypoxiaf463173 × 10−15362106 × 10−7
    Galactoseg825308 × 10−27714257 × 10−24
    Biofilmh479311041 × 10−4244426911 × 10−39
    37°C, 10 mini814267 × 10−19714241 × 10−21
    Osmotic shock, 10 mini1067284 × 10−15946236 × 10−13
    3-ATj33622769 × 10−3330318607 × 10−24
    C starvationk1027255 × 10−12956217 × 10−10
Downregulated genes
    Cecum467
    Alkaline pHe2211612NS
    Hypoxiaf2012NS
    Biofilmh457341079 × 10−40
    37°C, 10 mini154118NS
    Osmotic shock, 10 mini10588NS
    Oxidative stress, 60 mini39393 × 10−3
    C starvationk31282 × 10−3
    3-ATj313231436 × 10−153
  • a Calculated as: (total genes) × (frequency upregulated in cecum) × (frequency upregulated under the indicated condition).

  • b That is, cecum upregulated genes that were also upregulated under the indicated condition.

  • c That is, the P value determined by the chi-square test. NS, not significant.

  • d Filtering to remove genes that were upregulated in hyphal cells was performed using the data of Goyard et al. (19) or Kadosh et al. (25).

  • e According to Bensen et al. (6).

  • f According to Setiadi et al. (50).

  • g According to Martchenko et al. (36).

  • h According to Nett et al. (40).

  • i According to Enjalbert et al. (15).

  • j According to Tournu et al. (62).

  • k According to Lorenz et al. (33).