TABLE 2.

Genes up-regulated by the cAMP signaling pathway in germ-tube-inducing conditionsa

GeneORF identityFold change between:Function of gene product
ORF6ORF19WTpde2pde2
cap1cap1WT
Hypha-specific or cell surface proteins
    ALS3137718163.015.971.98Cell surface adhesin, hypha induced
    ECE1288633743.038.652.85Unknown, hypha induced
    RBT1488913273.635.091.40Unknown, repressed by Tup1
    ECE99292933842.543.931.55Unknown, homologous to Rbt1
    PGA45124724512.003.891.94Putative GPI-anchored protein of unknown function
    HWP1488313212.393.621.51Cell surface adhesin, human transglutaminase substrate
    PDC11438628773.583.360.94Similar to pyruvate decarboxylase; antigenic; located at the cell surface of hyphae, but not yeast
Cytoskeleton/microtubules
    STU11622266102.152.961.38Structural constituent of cytoskeleton, mitotic spindles
Ergosterol biosynthesis and lipid metabolism
    ERG128164062.313.941.70Squalene monooxygenase
    ERG251205446312.253.891.73Homologous to C-4 methyl sterol oxidase encoded by ERG25
    SUR2404158183.083.020.98Predicted enzyme of sphingolipid biosynthesis
    ERG1128669223.292.990.91Lanosterol 14 α-demethylase
Fermentation
    PDC12790746082.663.001.13Putative pyruvate decarboxylase, fungus specific
    ADH2633751132.282.180.95Putative alcohol dehydrogenase, fungus specific
Glycolysis or gluconeogenesis
    HGT8237720212.603.391.30Hexose transport
    CDC19575435752.282.951.29Pyruvate kinase
    HGT7237620232.982.910.98Hexose transport
    PFK1350439672.952.520.85Alpha subunit of phosphofructokinase
    HGT6237920202.742.490.91Putative glucose transporter of the major facilitator superfamily
    GPM2492210672.472.250.91Phosphoglycerate mutase
    GPM172749032.222.221.00Phosphoglycerate mutase
    TPI1888613061.852.161.17Triose-phosphate isomerase
    HGT7121020231.902.161.14Hexose transport
    TDH3881768141.692.091.23Glyceraldehyde 3-phosphate dehydrogenase
    PFK2527439672.261.930.86Beta subunit of phosphofructokinase
Heme binding/biosynthetic pathway
    ORF6.2323232310341.892.761.46Homologous to S. cerevisiae Dap1p, caspofungin repressed
Oxidoreductase
    IFE2382752881.972.921.48Alcohol dehydrogenase, Efg1 regulated
Stress-associated protein
    PHO15725744442.221.960.884-Nitrophenyl phosphatase, induced by heavy metal
Unknown
    UCF11464135410.3510.290.99Down-regulation correlates with fluconazole resistance
    ORF6.6008600823721.653.061.85Unknown, similar to the Tca2 (pCal) retrotransposon
    SEC65380625571.962.761.41Unknown, potential signal recognition particle
    ORF6.29429424521.412.751.96Unknown, transcriptionally regulated by iron
    ORF6.4769476923712.132.671.26Unknown, similar to the Tca2 (pCal) retrotransposon
    YCL019W477023722.002.561.28Unknown, similar to the Tca2 (pCal) retrotransposon
    ORF6.7250725032622.262.551.13Unknown
    ORF6.16216289792.092.441.17Unknown, expression greater at high iron concentrations
    ORF6.7932793270061.852.051.11Unknown
    YFR044C513239152.161.910.88Unknown, Hog1 induced
  • a Significant duplicates were averaged.