TABLE 3.

Genes down-regulated by the cAMP signaling pathway in germ-tube-inducing conditionsa

GeneORF identityFold change between:Function of gene product
ORF6ORF19cap1cap1WT
WTpde2pde2
Aldehyde metabolism
    ALD4549963061.492.561.72Aldehyde dehydrogenase (NAD) activity
    IFD74256291.642.211.35Similar to aryl-alcohol dehydrogenases
    ALD5664058061.372.211.61Aldehyde dehydrogenase
Amino acid/protein biosynthesis
    LYS22419845062.562.601.01Putative homocitrate synthase, fungus specific
    RPP0794170151.212.542.11Putative ribosomal protein
    CSP37238825312.462.481.01Protein complex assembly
    RPL12643716351.842.411.31Predicted ribosomal protein
    RPL10A376834652.162.361.09Predicted ribosomal protein
    ILV53699881.262.331.85Keto-acid reductoisomerase
    ACO1787063852.062.281.10Protein described as aconitase, glutamate biosynthesis
    RPL23A436435041.921.991.03Putative ribosomal protein
    HOM6666529511.281.951.525-Amino-6-(5-phosphoribosylamino)uracil reductase
    ASN159301981.951.951.00Asparagine synthetase, soluble protein in hyphae
    RPP1A487329921.711.951.14Conserved acidic ribosomal protein
    IDH1738548261.451.781.22Isocitrate dehydrogenase (NAD+) activity
    HIP1187831951.301.761.35Amino acid permease activity, amino acid transport
    TUF1759160471.651.691.02Putative translation elongation factor
Arginine catabolism
    CAR2451056411.661.891.14Unknown, alkaline up-regulated
Axial bud site selection
    BUD3847470791.111.581.42Axial bud site selection
Cell surface protein
    ALS4307545562.713.031.12Member of the ALSb GPI-anchored protein family
    ALS2299910972.444.171.71Member of the ALS GPI-anchored protein family
Endoplasmic reticulum protein
    YET3642115641.541.841.20Unknown, Yet3p analog
Fatty acid catabolism
    ARD1551563221.642.011.23 d-Arabitol dehydrogenase, NAD dependent
Glycine metabolism
    SHM2209157501.402.431.73Cytoplasmic serine hydroxymethyltransferase
Metabolism
    MAM33808771871.422.351.65Possible role in aerobic respiration
Mitochondria
    MRH4497834811.942.551.32Mitochondrial RNA helicase
    RSM23497934802.271.990.87Ribosomal small subunit of mitochondria
Nucleotide biosynthesis
    TFS1186119742.082.471.19Transcription is regulated upon yeast-hypha switch
    URA4140719771.681.771.06Nucleotide biosynthesis
Purine base metabolism
    ADE4508412331.811.871.04Unknown, flucytosine induced
Stress-associated protein
    HSP12276142163.584.661.30Heat shock protein, cell adhesion (oxidative stress response)
    CCP19572382.352.951.25Cytochrome c peroxidase (oxidative stress response)
    MCR1436735071.872.911.55Cytochrome b5 reductase
    SOD2473133401.472.411.64Mn-superoxide dismutase (oxidative stress response)
Transporter
    MUP1766252801.642.141.30Alkaline up-regulated by Rim101p, sulfur amino acid transport
    YOR1253117831.512.071.37ATPase, ATP binding
    CHS7362224441.281.991.56Endoplasmic-reticulum-to-Golgi-vesicle-mediated transport
    MIR1305148851.161.901.64Putative mitochondrial phosphate transporter
Unknown
    MAP2765365071.011.861.83Unknown
    TOM40763665241.411.811.29Unknown, protein transporter activity
  • a Significant duplicates were averaged.

  • b ALS, agglutinin-like sequence.