TABLE 1.

Components involved in the HOG signaling pathway

Signaling componentaNonpathogenic model fungiPathogenic fungi
S. cerevisiaeS. pombeN. crassaA. nidulansA. fumigatusC. albicansC. neoformans
Hybrid HKSln1Mak1Nik-1/Os-1Nik1TcsA/Fos1Sln1Tco1
Mak2NCU00939bTcsATcsBChk1Tco2
Mak3NCU00939bTcsBAfu2g00660bNik1Tco3/Phy1
NCU01823bFphAAfu2g03560bTco4
NCU01833bAN2363bAfu3g07130bTco5
NCU02057bAN2581bAfu3g12530bTco6b
NCU03164bAN3101bAfu3g12550bTco7
NCU04615bAN3102bAfu4g00320b
PHY-1AN3214bAfu4g00660b
PHY-2AN4113bAfu4g01020b
NCU07221bAN4447bAfu4g02900b
NCU09520bAN4818bAfu4g07400b
AN6820bAfu6g09260b
AN7945bAfu8g06140b
AN9048b
HPtYpd1Mpr1/Spy1HPT-1YpdAAfu4g10280bYpd1Ypd1b
RRSsk1Mcs4RRG-1SskAAfu5g08390bSsk1Ssk1
Skn7Prr1RRG-2SrrAAfu6g12520bSkn7Skn7
MAPKKKSsk2Wak1/Wik1/Wis4Os-4SskBAfu1g10940bSsk2Ssk2
MAPKKPbs2Wis1Os-5PbsBAfu1g15950bPbs2Pbs2
MAPKHog1Sty1/Spc1/Phh1Os-2SakA/HogASakA/HogAHog1Hog1
TFMsn1Atf1NcSgd1bAnSgdAbAfSgdAbSko1Sgd1b
Msn2/4Pap1(NCU02406)(AN4581)(Afu2g01980)Hot1b(CNAG_06228)
Sko1Prr1NcAtf1bAnAtfAbAfAtfAb(orf19.1987)Atf1
Hot1(NCU01345)(AN2911)(Afu3g11330)Sgd1b(CNAG_04090)
Smp1NcPap1bAnPapAbAfPapAb(orf19.4363)
Sgd1(NCU03905)(AN7513)(Afu6g09930)Pap1b
Skn7(orf19.3197)
PhosphatasePtp2Pyp1Ptc1bPtc1bPtc1bPtp2bPtp2b
Ptp3Pyp2(NCU00434)(AN6892)(Afu5g13340)(orf19.5045)(CNAG_05155)
Ptc1Ptc1Ptc2bPtc2bPtc2bPtp3bPtc1b
Ptc2Ptc3(NCU04600)(AN1358)(Afu1g09280)(orf19.7610)(CNAG_00500)
Ptc3Ptp2bPtp2bPtp2bPtc1bPtc2b
(NCU05364)(AN6982)(Afu4g04710)(orf19.4785)(CNAG_03052)
Ptc2b
(orf19.2538)
  • a Abbreviations: HK, hybrid histidine kinase; RR, response regulator; TF, Hog1-dependent transcription factors.

  • b Signaling component identified by BLAST search in the corresponding genome database but not experimentally confirmed.