TABLE 3.

Summary of mutant phenotypes compared to wild type

Mutated genePutative role in SREBP pathwayDefective processingDefective turnoverSensitivity to low O2Ergosterol abnormalityAzole sensitivityCoCl2 sensitivityNaNO2 sensitivityROS sensitivityfVirulence
sreITranscriptional factorNDaNDaYesYesYesYesYesYesNo
scpICleavage activating proteinYesYesYesYesYesYesYesYesReduced
sfb2ER-to-Golgi complex transportYesYesNobYesYesNo?eYesNot tested
stpIProteolytic cleavageYesYesYesYesYesYesYesYesNo
kap123Nuclear transportYesYesYesNoNoYesNoYesYes
gsk3Phosphorylation, turnoverNoYesYesNoYesdYesYesYesNo
dam1Turnover?NoYesNocNoNoYesNoYesNot tested
  • a ND, not detectable due to deletion.

  • b Temperature sensitive at 37°C.

  • c Mutation can only be partially complemented.

  • d Slightly increased susceptibility.

  • e Could not be determined due to sensitivity at pH 4.

  • f Sensitive to at least one of the ROS reagents tested.