Summary of mutant phenotypes compared to wild type

Mutated genePutative role in SREBP pathwayDefective processingDefective turnoverSensitivity to low O2Ergosterol abnormalityAzole sensitivityCoCl2 sensitivityNaNO2 sensitivityROS sensitivityfVirulence
sreITranscriptional factorNDaNDaYesYesYesYesYesYesNo
scpICleavage activating proteinYesYesYesYesYesYesYesYesReduced
sfb2ER-to-Golgi complex transportYesYesNobYesYesNo?eYesNot tested
stpIProteolytic cleavageYesYesYesYesYesYesYesYesNo
kap123Nuclear transportYesYesYesNoNoYesNoYesYes
gsk3Phosphorylation, turnoverNoYesYesNoYesdYesYesYesNo
dam1Turnover?NoYesNocNoNoYesNoYesNot tested
  • a ND, not detectable due to deletion.

  • b Temperature sensitive at 37°C.

  • c Mutation can only be partially complemented.

  • d Slightly increased susceptibility.

  • e Could not be determined due to sensitivity at pH 4.

  • f Sensitive to at least one of the ROS reagents tested.