TABLE 3.

Summary of mutant phenotypes compared to wild type

Mutated genePutative role in SREBP pathwayDefective processingDefective turnoverSensitivity to low O2Ergosterol abnormalityAzole sensitivityCoCl2 sensitivityNaNO2 sensitivityROS sensitivityfVirulence
sreI Transcriptional factorNDaNDaYesYesYesYesYesYesNo
scpI Cleavage activating proteinYesYesYesYesYesYesYesYesReduced
sfb2 ER-to-Golgi complex transportYesYesNobYesYesNo?eYesNot tested
stpI Proteolytic cleavageYesYesYesYesYesYesYesYesNo
kap123 Nuclear transportYesYesYesNoNoYesNoYesYes
gsk3 Phosphorylation, turnoverNoYesYesNoYesdYesYesYesNo
dam1 Turnover?NoYesNocNoNoYesNoYesNot tested
  • a ND, not detectable due to deletion.

  • b Temperature sensitive at 37°C.

  • c Mutation can only be partially complemented.

  • d Slightly increased susceptibility.

  • e Could not be determined due to sensitivity at pH 4.

  • f Sensitive to at least one of the ROS reagents tested.