TABLE 1.

High-amyloid-potential sequences in Als proteins

GeneSequence positionaSequenceβ-Aggregation potential (%)b
ALS5325IVIVATT93
ALS3325IVIVATT90
ALS1325IVIVATT90
ALS9325IIVVTT96
ALS6328AAVVVTT54
ALS4325ITIVVT65
ALS2324FVIVATT93
ALS7358TILVL80
  • a Amino acid sequence position of the first residue.

  • b TANGO β-aggregation potential.