TABLE 2.

Genetic interactionsa

MutationFunctionInteraction with
mcl1-1mcl1-GFPnmt41mcl1-MH
OnOff
mad2ΔSpindle assembly checkpointNINININI
bub1ΔSpindle assembly checkpoint kinaseSLNISSL
rad3ΔDNA damage checkpoint kinaseSLNISLSL
rad26ΔRad3 interaction proteinSLNISLSL
rad9ΔDNA damage checkpoint (PCNA like)SNINIS
hsk1-1312S-phase initiation kinaseSLNIMLML
cds1ΔTransducer kinase for S-phasePRNINIPR
rqh1ΔRecQ helicase homologSLNISLSL
pol1-1DNA polymerase-αNINININI
rad22ΔRad52 homologueNINI
rph51ΔRad51 homologueMLNI
rph54ΔRad54 homologueMLNI
  • a NI, no interaction; S, synthetic; SL, synthetic lethal; PR, partial rescue; and ML, meiotic lethal.