TABLE 3.

Drug susceptibility of S. cerevisiae cells overexpressing the wild type and mutant variant of Cdr1p

StrainMICa (μg/ml)
AnisoCyhFluMicNys
AD1-8u0.120.01510.0150.03
PSCDR1-GFP1616442
SS5G (F774A)80.51610.25
SS6G (ΔF774)0.120.01520.0150.03
  • a MICs were determined by a microdilution method as described in Materials and Methods. Aniso, anisomycin; Cyh, cycloheximide; Flu, fluconazole; Mic, miconazole; Nys, nystatin. The MIC test end point was defined as the MIC80.