TABLE 1.

Drug resistance phenotype of the tbat1-null mutant compared to the parental wild-type strain

DrugIC50a (ng/ml)Resistance factor
Wild typeTbAT1−/− mutant
Melarsoprol21 ± 349 ± 92.3
Melarsen oxide3.7 ± 0.111 ± 0.13.0
Cymelarsan6.1 ± 112 ± 32.0
Pentamidine5.1 ± 212 ± 32.4
Diminazene120 ± 302,300 ± 50019
Propamidine67 ± 7750 ± 2011
Stilbamidine680 ± 705,000 ± 1,3007.4
  • a IC50 were determined in vitro by using the Alamar Blue assay. Values are means from at least three independent experiments ± standard errors.