TABLE 5.

Genes upregulated by the G648D mutation in Upc2p

CandidaDB nameaCommon nameborf19 no.cGO annotation (molecular function)dFold increase in expression
S2 vs S1UPC2S2-1 vs UPC2S1-1
Strain AStrain B
Expt 1Expt 2Expt 1Expt 2Expt 1Expt 2
BMR1MDR1orf19.5604Multidrug transporter activity2.13.75.43.52.55.1
DDR48DDR48orf19.40827.18.02.43.42.43.8
ECM3ECM3orf19.15631.61.51.74.12.93.2
ERG1ERG1orf19.406Squalene monooxygenase activity2.41.61.51.71.61.8
ERG24ERG24orf19.1598Delta 14-sterol reductase activity2.32.03.22.93.52.9
ERG26ERG26orf19.2909C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity2.01.62.02.01.92.0
ERG27ERG27orf19.32403-Keto sterol reductase activity2.32.12.23.63.02.8
FEN2orf19.5535Pantothenate transporter activity2.22.22.32.72.72.8
FTH1FTH1orf19.48021.51.51.84.32.43.7
IDP2IDP2orf19.3733Isocitrate dehydrogenase (NADP+) activity3.62.11.81.61.81.7
IFA24.3FGR51orf19.1561.81.91.71.71.61.7
NCP1NCP1orf19.2672NADPH-hemoprotein reductase activity2.51.51.92.21.71.8
QRI8orf19.7329Ubiquitin-protein ligase activity1.52.01.61.71.51.7
TEF41TEF4orf19.2652Translation elongation factor activity4.13.418.828.919.014.9
IPF12101PGA7orf19.56351.62.75.48.86.09.0
IPF1218SOD4orf19.2062Copper-zinc superoxide dismutase activity2.32.32.21.71.81.6
IPF14119DAG7orf19.46881.81.61.71.61.71.8
IPF14652orf19.26534.31.61.72.84.31.9
IPF18080orf19.73571.91.61.51.81.61.6
IPF20010orf19.57992.02.22.22.81.62.0
IPF20169PGA10orf19.5674Heme binding4.110.85.613.07.011.1
IPF2903orf19.74561.82.32.01.72.21.6
IPF3352orf19.40132.32.32.02.51.92.0
IPF4059orf19.18651.62.12.72.51.92.4
IPF4721orf19.37371.51.62.31.51.81.6
IPF6298orf19.19643.01.61.71.72.31.7
IPF6518orf19.16913.35.31.72.32.02.7
IPF7289UPC2orf19.391Transcription factor activity1.62.42.12.52.42.5
IPF7397orf19.18002.92.61.81.71.62.2
IPF7432orf19.62192.02.31.92.42.12.2
IPF867SET3orf19.7221NAD-dependent histone deacetylase activity2.11.73.62.93.22.4
IPF8970orf19.4961.92.52.21.91.61.8