TABLE 5.

Genes upregulated by the G648D mutation in Upc2p

CandidaDB nameaCommon nameborf19 no.cGO annotation (molecular function)dFold increase in expression
S2 vs S1UPC2S2-1 vs UPC2S1-1
Strain AStrain B
Expt 1Expt 2Expt 1Expt 2Expt 1Expt 2
BMR1 MDR1 orf19.5604Multidrug transporter activity2.13.75.43.52.55.1
DDR48 DDR48 orf19.40827.18.02.43.42.43.8
ECM3 ECM3 orf19.15631.61.51.74.12.93.2
ERG1 ERG1 orf19.406Squalene monooxygenase activity2.41.61.51.71.61.8
ERG24 ERG24 orf19.1598Delta 14-sterol reductase activity2.32.03.22.93.52.9
ERG26 ERG26 orf19.2909C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity2.01.62.02.01.92.0
ERG27 ERG27 orf19.32403-Keto sterol reductase activity2.32.12.23.63.02.8
FEN2 orf19.5535Pantothenate transporter activity2.22.22.32.72.72.8
FTH1 FTH1 orf19.48021.51.51.84.32.43.7
IDP2 IDP2 orf19.3733Isocitrate dehydrogenase (NADP+) activity3.62.11.81.61.81.7
IFA24.3 FGR51 orf19.1561.81.91.71.71.61.7
NCP1 NCP1 orf19.2672NADPH-hemoprotein reductase activity2.51.51.92.21.71.8
QRI8 orf19.7329Ubiquitin-protein ligase activity1.52.01.61.71.51.7
TEF41 TEF4 orf19.2652Translation elongation factor activity4.13.418.828.919.014.9
IPF12101 PGA7 orf19.56351.62.75.48.86.09.0
IPF1218 SOD4 orf19.2062Copper-zinc superoxide dismutase activity2.32.32.21.71.81.6
IPF14119 DAG7 orf19.46881.81.61.71.61.71.8
IPF14652 orf19.26534.31.61.72.84.31.9
IPF18080 orf19.73571.91.61.51.81.61.6
IPF20010 orf19.57992.02.22.22.81.62.0
IPF20169 PGA10 orf19.5674Heme binding4.110.85.613.07.011.1
IPF2903 orf19.74561.82.32.01.72.21.6
IPF3352 orf19.40132.32.32.02.51.92.0
IPF4059 orf19.18651.62.12.72.51.92.4
IPF4721 orf19.37371.51.62.31.51.81.6
IPF6298 orf19.19643.01.61.71.72.31.7
IPF6518 orf19.16913.35.31.72.32.02.7
IPF7289 UPC2 orf19.391Transcription factor activity1.62.42.12.52.42.5
IPF7397 orf19.18002.92.61.81.71.62.2
IPF7432 orf19.62192.02.31.92.42.12.2
IPF867 SET3 orf19.7221NAD-dependent histone deacetylase activity2.11.73.62.93.22.4
IPF8970 orf19.4961.92.52.21.91.61.8