TABLE 3.

Conservation of key residues in cyclophilinsa

ProteinLengthPosition% ConservedTargetP prediction
5560121126
PPIA_HUMAN165RFWH100— (2)
CYN16 C_240021 modified190**Q*75— (3)
CYN17 C_20323 180*GFR25— (2)
CYN18-1 C_20046 modified 162**HY50— (3)
CYN18-2 C_1010007157****100— (2)
CYN19-1 C_250142>338****100— (2)
CYN19-2 C_3230001172****100— (2)
CYN19-3 C_790042201****100— (3)
CYN20-1 C_290072222****100S (4): 36
CYN20-2 C_70215243****100C (4): 39
CYN20-3 C_740054200****100M (2): 30
CYN20-4 C_990048 229XX<50— (4)
CYN20-5 C_660007340**H*75M (4): 48
CYN22 C_910055187****100— (3)
CYN23 C_2260002 235**HY50S (2): 19
CYN26-2 C_460089 modified 310GYDN0C (4): 40
CYN28 C_1220009 modified 350*ERN25C (3): 45
CYN37 C_90033 288AVAF0— (3)
CYN38 C_30248 modified 413**NF50M (4): 27
CYN40 C_180001369**H*75— (4)
CYN51 C_200140 modified 465**HY50M (4): 9
CYN52 C_1560006 modified482**H*75S (1): 28
CYN53 C_1560025 modified 583**HY50M (3): 12
CYN57 C_1280001 585*Y*N50S (3): 24
CYN59 C_480065 modified 486N*S*50— (3)
CYN65 C_800078 modified586**H*100— (4)
CYN71 C_320104/C_19080001 ?**<50?
AtCYP18-1 At1g01940 160**HY50— (4)
AtCYP18-2 At2g36130164**S*100— (3)
AtCYP18-3 At4G38740172****100— (2)
AtCYP18-4 At4G34870172****100— (3)
AtCYP19-1 At2G16600173****100— (2)
AtCYP19-2 At2g21130174****100— (2)
AtCYP19-3 At3g56070176****100— (5)
AtCYP19-4 At2G29960201****100S (1): 23
AtCYP20-1 At5G58710204****100S (1): 23
AtCYP20-2 At5g13120259****100C (1): 70
AtCYP20-3 At3g62030260****100C (1): 77
AtCYP21-1 At4g34960224****100S (2): 27
AtCYP21-2 At3g55920228****100S (1): 31
AtCYP21-3 At2G47320 230**DL50M (4): 47
AtCYP21-4 At3G66654 236*YDL25C (4): 61
AtCYP22 At2g38730199****100— (5)
AtCYP23 At1g26940 226**HY50S (1): 22
AtCYP26-1 At3g22920 232HLQ*25— (3)
AtCYP26-2 At1g74070 314KYEV0C (1): 45
AtCYP28 At5g35100 289KQQN0C (2): 70
AtCYP37 At3g15520 464TASF0C (2): 65
AtCYP38 At3g01480 437**NY50C (1): 36
AtCYP40 At2g15790361**H*75— (2)
AtCYP57 At4g33060504****100— (1)
AtCYP59 At1g53720 506T*Y*50— (4)
AtCYP63 At3g63400570**H*75— (4)
AtCYP65 At5g67530595**H*100— (2)
AtCYP71 At3g44600631****100— (3)
AtCYP95 At4g32420 837*SQN25— (2)
CMH263C238**P*75S (2): 22
CMO300C168****100— (2)
CMP271C 310YAEN0C (5): 47
CMR272C251**Q*75C (5): 78
NP_385689_S_meliloti 190**FY50S (1): 23
NP_385690_S_meliloti 169***Y75— (2)
sll0227 Syn 6803 246**GY50S (2): 28
sll0408 Syn 6803 403**NY50— (2)
slr1251 Syn 6803170****100— (2)
  • a IsoformspresumedtobeinactiveasPPlaseareinitalics.IntracellulartargetingpredictedbyTargetPisindicated(C,chloroplast; M, mitochondrion; S, secretory pathway;— ,none),togetherwiththelevelofconfidence(1,highest;4,lowest)andthepredictedlengthofthetransitpeptide.*,identitytoPPIA_HUMAN.