TABLE 2.

Conservation of key residues in FKBPsa

ProteinResidue at aa position:% ConservedbTargetP prediction
27373843475556576082838892100
FKBP12_humanYFDRFEVIWAYHIF100— (2)
FKB12 C_230098:::::::::::I:86— (2)
FKB15-1 C_480074:::::S:::G:GK:71S (2): 23
FKB15-2 C_480037::::IQ:::::G:71S (1): 22
FKB15-4 C_480038::::IQ:::G:G:64S (1): 22
FKB16-1 C_440012 :IYFV:L:LG:GP:36C (4): 56
FKB16-2A C_580070::::LQ:::G:GV:64M (3): 26
FKB16-3 C_380115 :::KYQ::L:FAR:50M (5): 46
FKB16-4 C_1080039 :MTGLGTLLG:LEI14C (5): 27
FKB16-5 C_580071::::LQ:::G:GV:64M (3): 23
FKB16-6 :XXXXSLPVGWKA:>14C (3): 51
FKB16-7 C_3330006 FLQLLRLFFGLVAI0C (3): 82
FKB16-8 C_140146 :MTGYN:LL::KEL29C (1): 78
FKB16-9 C_320049 V:LELY:TLG:KRY21C (2): 36
FKB17-1 C_220072 :::YAP:IGFAAY29M (3): 70
FKB17-2 C_140132 ::E:IPFTNGFGRY21M (4): 113
FKB18 C 1630014 :VSGYKPPLG:GL14C (4): 29
FKB19 C_910042 W:EKYK::FG:NL:36M (4): 12
FKB20-2 C_210108 :I:QAGM:FGPGF:29C (4): 31
FKB42 C_680056 :M:TVAQELG:FCY21— (2)
FKB53 :::G:NHLL::XXX>43— (4)
FKB62:::::FEA:::V:64— (2)
FKB99 C_280158 :YSGYR:P:G:MV29— (4)
TIG1 C_4210001+2 GEIG:VIDVSK:14M (2): 63
AtFKBP12 AT5G64350C:WE:A:::::FG:57— (3)
AtFKBP13 AT5G45680::::L::::::KC:79C (3): 14
AtFKBP15-1 AT3G25220::::IQ:::G:GK:64S (3): 18
AtFKBP15-2 AT5G48580:::::Q:::G:GT:71S (1): 25
AtFKBP15-3 AT5G05420 :::KYK::LG:GS:50— (3)
AtFKBP16-1 AT4G26555 :HSSVD::LG:T::43C (1): 71
AtFKBP16-2 AT4G39710::::LK::L::SNY57C (3): 34
AtFKBP16-3 AT2G43560 :::KYQ::L:FSR:50C (2): 36
AtFKBP16-4 AT3G10060 WI::YQA:F::DR:43C (2): 56
AtFKBP17-1 AT4G19830:::H:K::IG:SL:57C (3): 63
AtFKBP17-2 AT1G18170 LV:KLPYSLGFGEY7C (3): 79
AtFKBP17-3 AT1G73655 VV:KLPYSLGFGEY7C (3): 28
AtFKBP18 AT1G20810 FISAYKPPMG:GL7C (4): 67
AtFKBP19 AT5G13410 W:EK::::FG:DS:50C (1): 29
AtFKBP20-1 AT3G55520:::D:S:::::GD:71— (2)
AtFKBP20-2 AT3G60370 :I:QAALVFGPGF:21C (2): 31
AtFKBP42 AT3G21640 ::EEIKELL::FNY29— (2)
AtFKBP43 At3g12330 :::ELN::LG:GKY43— (4)
AtFKBP53 AT4G25340:::K:S:::G:GQ:64
AtFKBP62 AT3G25230:::::Q:::::S:79— (1)
AtFKBP65 AT5G48570:::::H:::::S:79— (2)
AtFKBP72 AT3G54010 :Y:NLL:PF::PGW36
AtTIG AT5G55220ESAG:RLLFKQGQ:14C (3): 26
CMD070C F::S:NLVV:FSY29C (3): 38
CMH076C:::::Q:::::I:79M (4): 7
CMH114C:::::S:::::V:79C (1): 41
CMH207C:::::S:::::A:79M (3): 117
CMO042C :IEGVTLPVNFRY7M (4): 11
CMT472C :::KLQMVVGFIY21C (2): 51
NP_414569.1 coli FAENASLSL:FYR:14— (3)
NP_417806.1_coli::::L:::::AG:71S (1): 25
NP_418628.3_coli::::A:::::RA:71S (4): 27
slr1761 Syn 6803:::::Q:::::RG:79M (3): 107
% Conserved7765673935960604044722465
  • a IsoformspresumedtobeinactiveasPPlaseareinitalics.IntracellulartargetingpredictedbyTargetPisindicated(C,chloroplast;M,mitochondrion; S, secretory pathway; —, none),togetherwiththelevelofconfidence(1,highest;4,lowest)andthepredictedlengthofthetransitpeptide.“:”indicatesidentitytohumanFKBP12.

  • b With respect to human FKBP12.