RT Journal Article
SR Electronic
T1 African Trypanosomes Contain 5-Methylcytosine in Nuclear DNA
JF Eukaryotic Cell
JO Eukaryot Cell
FD American Society for Microbiology
SP 2012
OP 2016
DO 10.1128/EC.00198-08
VO 7
IS 11
A1 Militello, Kevin T.
A1 Wang, Ping
A1 Jayakar, Sangeeta K.
A1 Pietrasik, Rebecca L.
A1 Dupont, Christopher D.
A1 Dodd, Kristi
A1 King, Anthony M.
A1 Valenti, Paul R.
YR 2008
UL http://ec.asm.org/content/7/11/2012.abstract
AB It is currently unclear if there are modified DNA bases in Trypanosoma brucei other than J-base. We identify herein a cytosine-5 DNA methyltransferase gene and report the presence and location of 5-methylcytosine in genomic DNA. Our data demonstrate that African trypanosomes contain a functional cytosine DNA methylation pathway.