A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a Clinical Candida albicans Isolate

Nico Dunkel; Teresa T. Liu; Katherine S. Barker; Ramin Homayouni; Joachim Morschhäuser; P. David Rogers

doi:10.1128/EC.00103-08

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A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a Clinical Candida albicans Isolate

Nico Dunkel, Teresa T. Liu, Katherine S. Barker, Ramin Homayouni, Joachim Morschhäuser, P. David Rogers

Nico Dunkel

1Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany

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Teresa T. Liu

2Departments of Clinical Pharmacy

4Molecular Sciences

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Katherine S. Barker

2Departments of Clinical Pharmacy

6Children's Foundation Research Center of Memphis, Le Bonheur Children's Medical Center, Memphis, Tennessee 38103

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Ramin Homayouni

7Bioinformatics Program, University of Memphis, Memphis, Tennessee 38152

8Department of Biology, University of Memphis, Memphis, Tennessee 38152

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Joachim Morschhäuser

1Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Germany

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For correspondence: joachim.morschhaeuser@mail.uni-wuerzburg.de drogers@utmem.edu

P. David Rogers

2Departments of Clinical Pharmacy

3Pharmaceutical Sciences

4Molecular Sciences

5Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38163

6Children's Foundation Research Center of Memphis, Le Bonheur Children's Medical Center, Memphis, Tennessee 38103

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For correspondence: joachim.morschhaeuser@mail.uni-wuerzburg.de drogers@utmem.edu

DOI: 10.1128/EC.00103-08

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A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a Clinical Candida albicans Isolate

Nico Dunkel, Teresa T. Liu, Katherine S. Barker, Ramin Homayouni, Joachim Morschhäuser, P. David Rogers

Eukaryotic Cell Jul 2008, 7 (7) 1180-1190; DOI: 10.1128/EC.00103-08

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A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a Clinical Candida albicans Isolate