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High Resistance to Oxidative Stress in the Fungal Pathogen Candida glabrata Is Mediated by a Single Catalase, Cta1p, and Is Controlled by the Transcription Factors Yap1p, Skn7p, Msn2p, and Msn4p

Mayra Cuéllar-Cruz, Marcela Briones-Martin-del-Campo, Israel Cañas-Villamar, Javier Montalvo-Arredondo, Lina Riego-Ruiz, Irene Castaño, Alejandro De Las Peñas
Mayra Cuéllar-Cruz
División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México
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Marcela Briones-Martin-del-Campo
División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México
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Israel Cañas-Villamar
División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México
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Javier Montalvo-Arredondo
División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México
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Lina Riego-Ruiz
División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México
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Irene Castaño
División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México
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Alejandro De Las Peñas
División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México
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  • For correspondence: cano@ipicyt.edu.mx
DOI: 10.1128/EC.00011-08
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ABSTRACT

We characterized the oxidative stress response of Candida glabrata to better understand the virulence of this fungal pathogen. C. glabrata could withstand higher concentrations of H2O2 than Saccharomyces cerevisiae and even Candida albicans. Stationary-phase cells were extremely resistant to oxidative stress, and this resistance was dependent on the concerted roles of stress-related transcription factors Yap1p, Skn7p, and Msn4p. We showed that growing cells of C. glabrata were able to adapt to high levels of H2O2 and that this adaptive response was dependent on Yap1p and Skn7p and partially on the general stress transcription factors Msn2p and Msn4p. C. glabrata has a single catalase gene, CTA1, which was absolutely required for resistance to H2O2 in vitro. However, in a mouse model of systemic infection, a strain lacking CTA1 showed no effect on virulence.

  • Copyright © 2008 American Society for Microbiology
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High Resistance to Oxidative Stress in the Fungal Pathogen Candida glabrata Is Mediated by a Single Catalase, Cta1p, and Is Controlled by the Transcription Factors Yap1p, Skn7p, Msn2p, and Msn4p
Mayra Cuéllar-Cruz, Marcela Briones-Martin-del-Campo, Israel Cañas-Villamar, Javier Montalvo-Arredondo, Lina Riego-Ruiz, Irene Castaño, Alejandro De Las Peñas
Eukaryotic Cell May 2008, 7 (5) 814-825; DOI: 10.1128/EC.00011-08

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High Resistance to Oxidative Stress in the Fungal Pathogen Candida glabrata Is Mediated by a Single Catalase, Cta1p, and Is Controlled by the Transcription Factors Yap1p, Skn7p, Msn2p, and Msn4p
Mayra Cuéllar-Cruz, Marcela Briones-Martin-del-Campo, Israel Cañas-Villamar, Javier Montalvo-Arredondo, Lina Riego-Ruiz, Irene Castaño, Alejandro De Las Peñas
Eukaryotic Cell May 2008, 7 (5) 814-825; DOI: 10.1128/EC.00011-08
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KEYWORDS

Candida glabrata
Candidiasis
Catalase
Oxidative Stress
Transcription Factors

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