African Trypanosomes Contain 5-Methylcytosine in Nuclear DNA

Kevin T. Militello; Ping Wang; Sangeeta K. Jayakar; Rebecca L. Pietrasik; Christopher D. Dupont; Kristi Dodd; Anthony M. King; Paul R. Valenti

doi:10.1128/EC.00198-08

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African Trypanosomes Contain 5-Methylcytosine in Nuclear DNA

Kevin T. Militello, Ping Wang, Sangeeta K. Jayakar, Rebecca L. Pietrasik, Christopher D. Dupont, Kristi Dodd, Anthony M. King, Paul R. Valenti

Kevin T. Militello

1State University of New York at Geneseo, Department of Biology, Geneseo, New York

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For correspondence: militello@geneseo.edu

Ping Wang

2Roswell Park Cancer Institute, Pharmacokinetics/Pharmacodynamics Facility, Buffalo, New York

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Sangeeta K. Jayakar

1State University of New York at Geneseo, Department of Biology, Geneseo, New York

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Rebecca L. Pietrasik

1State University of New York at Geneseo, Department of Biology, Geneseo, New York

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Christopher D. Dupont

1State University of New York at Geneseo, Department of Biology, Geneseo, New York

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Kristi Dodd

1State University of New York at Geneseo, Department of Biology, Geneseo, New York

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Anthony M. King

1State University of New York at Geneseo, Department of Biology, Geneseo, New York

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Paul R. Valenti

1State University of New York at Geneseo, Department of Biology, Geneseo, New York

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DOI: 10.1128/EC.00198-08

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ABSTRACT

It is currently unclear if there are modified DNA bases in Trypanosoma brucei other than J-base. We identify herein a cytosine-5 DNA methyltransferase gene and report the presence and location of 5-methylcytosine in genomic DNA. Our data demonstrate that African trypanosomes contain a functional cytosine DNA methylation pathway.

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African Trypanosomes Contain 5-Methylcytosine in Nuclear DNA

Kevin T. Militello, Ping Wang, Sangeeta K. Jayakar, Rebecca L. Pietrasik, Christopher D. Dupont, Kristi Dodd, Anthony M. King, Paul R. Valenti

Eukaryotic Cell Nov 2008, 7 (11) 2012-2016; DOI: 10.1128/EC.00198-08

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