DOI: 10.1128/EC.00274-06
ABSTRACT
Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.
FOOTNOTES
- Received 28 August 2006.
- Accepted 11 October 2006.
↵▿ Published ahead of print on 20 October 2006.
- American Society for Microbiology
Genetic Architecture of Hsp90-Dependent Drug Resistance
