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Genetic Architecture of Hsp90-Dependent Drug Resistance

Leah E. Cowen, Anne E. Carpenter, Oranart Matangkasombut, Gerald R. Fink, Susan Lindquist
Leah E. Cowen
1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142
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Anne E. Carpenter
1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142
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Oranart Matangkasombut
2Department of Microbiology, School of Dentistry, Chulalongkorn University, Bangkok 10330, Thailand
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Gerald R. Fink
1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142
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Susan Lindquist
1Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142
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  • For correspondence: Lindquist_admin@wi.mit.edu
DOI: 10.1128/EC.00274-06
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ABSTRACT

Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.

  • Copyright © 2006 American Society for Microbiology
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Genetic Architecture of Hsp90-Dependent Drug Resistance
Leah E. Cowen, Anne E. Carpenter, Oranart Matangkasombut, Gerald R. Fink, Susan Lindquist
Eukaryotic Cell Dec 2006, 5 (12) 2184-2188; DOI: 10.1128/EC.00274-06

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Genetic Architecture of Hsp90-Dependent Drug Resistance
Leah E. Cowen, Anne E. Carpenter, Oranart Matangkasombut, Gerald R. Fink, Susan Lindquist
Eukaryotic Cell Dec 2006, 5 (12) 2184-2188; DOI: 10.1128/EC.00274-06
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KEYWORDS

HSP90 Heat-Shock Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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