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The Forkhead Transcription Factor Fkh2 Regulates the Cell Division Cycle of Schizosaccharomyces pombe

Richard Bulmer, Aline Pic-Taylor, Simon K. Whitehall, Kate A. Martin, Jonathan B. A. Millar, Janet Quinn, Brian A. Morgan
Richard Bulmer
1Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
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Aline Pic-Taylor
1Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
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Simon K. Whitehall
1Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
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Kate A. Martin
1Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
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Jonathan B. A. Millar
2Division of Yeast Genetics, National Institute for Medical Research, London NW7 1AA, United Kingdom
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Janet Quinn
1Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
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Brian A. Morgan
1Institute of Cell and Molecular Biosciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH
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  • For correspondence: b.a.morgan@ncl.ac.uk
DOI: 10.1128/EC.3.4.944-954.2004
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ABSTRACT

In eukaryotes the regulation of gene expression plays a key role in controlling cell cycle progression. Here, we demonstrate that a forkhead transcription factor, Fkh2, regulates the periodic expression of cdc15+ and spo12+ in the M and G1 phases of the cell division cycle in the fission yeast Schizosaccharomyces pombe. We also show that Fkh2 is important for several cell cycle processes, including cell morphology and cell separation, nuclear structure and migration, and mitotic spindle function. We find that the expression of fkh2+ is itself regulated in a cell cycle-dependent manner in G1 coincident with the expression of cdc18+, a Cdc10-regulated gene. However, fkh2+ expression is independent of Cdc10 function. Fkh2 was found to be phosphorylated during the cell division cycle, with a timing that suggests that this posttranslational modification is important for cdc15+ and spo12+ expression. Related forkhead proteins regulate G2 and M phase-specific gene expression in the evolutionarily distant Saccharomyces cerevisiae, suggesting that these proteins play conserved roles in regulating cell cycle processes in eukaryotes.

  • Copyright © 2004 American Society for Microbiology
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The Forkhead Transcription Factor Fkh2 Regulates the Cell Division Cycle of Schizosaccharomyces pombe
Richard Bulmer, Aline Pic-Taylor, Simon K. Whitehall, Kate A. Martin, Jonathan B. A. Millar, Janet Quinn, Brian A. Morgan
Eukaryotic Cell Aug 2004, 3 (4) 944-954; DOI: 10.1128/EC.3.4.944-954.2004

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The Forkhead Transcription Factor Fkh2 Regulates the Cell Division Cycle of Schizosaccharomyces pombe
Richard Bulmer, Aline Pic-Taylor, Simon K. Whitehall, Kate A. Martin, Jonathan B. A. Millar, Janet Quinn, Brian A. Morgan
Eukaryotic Cell Aug 2004, 3 (4) 944-954; DOI: 10.1128/EC.3.4.944-954.2004
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KEYWORDS

Cell Cycle
Gene Expression Regulation, Fungal
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Transcription Factors

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