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Acetylcholine Protects against Candida albicans Infection by Inhibiting Biofilm Formation and Promoting Hemocyte Function in a Galleria mellonella Infection Model

Ranjith Rajendran, Elisa Borghi, Monica Falleni, Federica Perdoni, Delfina Tosi, David F. Lappin, Lindsay O'Donnell, Darren Greetham, Gordon Ramage, Christopher Nile
Ranjith Rajendran
aInfection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Elisa Borghi
bLaboratory of Microbiology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
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Monica Falleni
cDivision of Human Pathology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
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Federica Perdoni
bLaboratory of Microbiology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
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Delfina Tosi
cDivision of Human Pathology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
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David F. Lappin
aInfection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Lindsay O'Donnell
aInfection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Darren Greetham
dSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom
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Gordon Ramage
aInfection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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Christopher Nile
aInfection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
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DOI: 10.1128/EC.00067-15
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Article Information

DOI 
https://doi.org/10.1128/EC.00067-15
PubMed 
26092919

Published By 
American Society for Microbiology Journals
History 
  • Received April 17, 2015
  • Accepted June 15, 2015
  • Published online July 29, 2015.

Copyright & Usage 
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (June 19, 2015).
  • You are viewing the most recent version of this article.

Author Information

  1. Ranjith Rajendrana,
  2. Elisa Borghib,
  3. Monica Fallenic,
  4. Federica Perdonib,
  5. Delfina Tosic,
  6. David F. Lappina,
  7. Lindsay O'Donnella,
  8. Darren Greethamd,
  9. Gordon Ramagea and
  10. Christopher Nilea
  1. aInfection and Immunity Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
  2. bLaboratory of Microbiology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
  3. cDivision of Human Pathology, Department of Health Sciences, Università degli Studi di Milano, Milan, Italy
  4. dSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom
  • Address correspondence to Christopher Nile, christopher.nile{at}glasgow.ac.uk.
  • Citation Rajendran R, Borghi E, Falleni M, Perdoni F, Tosi D, Lappin DF, O'Donnell L, Greetham D, Ramage G, Nile C. 2015. Acetylcholine protects against Candida albicans infection by inhibiting biofilm formation and promoting hemocyte function in a Galleria mellonella infection model. Eukaryot Cell 14:834–844. doi:10.1128/EC.00067-15.

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Acetylcholine Protects against Candida albicans Infection by Inhibiting Biofilm Formation and Promoting Hemocyte Function in a Galleria mellonella Infection Model
Ranjith Rajendran, Elisa Borghi, Monica Falleni, Federica Perdoni, Delfina Tosi, David F. Lappin, Lindsay O'Donnell, Darren Greetham, Gordon Ramage, Christopher Nile
Eukaryotic Cell Jul 2015, 14 (8) 834-844; DOI: 10.1128/EC.00067-15

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Acetylcholine Protects against Candida albicans Infection by Inhibiting Biofilm Formation and Promoting Hemocyte Function in a Galleria mellonella Infection Model
Ranjith Rajendran, Elisa Borghi, Monica Falleni, Federica Perdoni, Delfina Tosi, David F. Lappin, Lindsay O'Donnell, Darren Greetham, Gordon Ramage, Christopher Nile
Eukaryotic Cell Jul 2015, 14 (8) 834-844; DOI: 10.1128/EC.00067-15
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