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Cover photograph (Copyright © 2009, American Society for Microbiology. All Rights Reserved.): Opening a genetic window for viewing the biology of the Apicomplexa. Plaque forming unit (PFU) assay of stained fibroblast monolayers showing total Toxoplasma gondii transformants in the wild-type RH strain (top left) or in the KU80 knockout strain (top right) with a targeting plasmid designed to disrupt the UPRT locus. A low frequency of gene targeting is observed in the wild-type RH strain (bottom left, no PFUs). In contrast, the KU80 knockout strain exhibits a high frequency (nearly 100%) of targeted disruption at the UPRT locus (bottom right). (See related article in the April 2009 issue: vol. 8, page 520–529.)
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