Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): Immunofluorescence labeling of a human erythrocyte infected with the malaria parasite, Plasmodium falciparum. The green fluorescence represents surface immunolabeling of the major virulence protein, PfEMP1. The red fluorescence is ethidium bromide staining of the parasite. (See related article on page 849.)