Cover photograph (Copyright © 2006, American Society for Microbiology. All Rights Reserved.): Venous catheter luminal surfaces after inoculation with wild-type Candida albicans (left) or a biofilm-defective hwp1/hwp1 mutant (right). These observations reveal that Hwp1 is the first cell surface protein required for biofilm formation in vivo. (See related article on page 1604.)

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