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Eukaryotic Cell doi:10.1128/EC.00369-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Effect of hydroxyurea on procyclic Trypanosoma brucei: An unconventional mechanism for achieving synchronous growth

Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205

^* To whom correspondence should be addressed. Email: penglund{at}jhmi.edu.

	Abstract

Procyclic Trypanosoma brucei were synchronized with 0.2 mM hydroxyurea. Cells did not arrest at the G1/S boundary but proceeded through one round of replication and arrested near the end of S phase. The mitochondrial genome (kinetoplast DNA network) replicated, forming two progeny networks but repair of minicircle gaps was inhibited.

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