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Eukaryotic Cell doi:10.1128/EC.00321-07
Copyright (c) 2007, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Functional characterization of Pneumocystis carinii brl1 by trans-species complementation analysis

Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Faculty of Life Sciences, EPFL, and Swiss Institute for Experimental Cancer Research (ISREC), Epalinges, Switzerland

^* To whom correspondence should be addressed. Email: philippe.hauser{at}chuv.ch.

	Abstract

Pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immuno-compromised humans. The brl1 gene of P. carinii infecting rats was identified and characterized using bioinformatics in conjunction with functional complementation in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the Brr6/Brl1 family in both yeasts.