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 Previous Article

Eukaryotic Cell, March 2009, p. 421-423, Vol. 8, No. 3
1535-9778/09/$08.00+0     doi:10.1128/EC.00374-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Contribution of Peroxisomes to Penicillin Biosynthesis in Aspergillus nidulans{triangledown} ,{dagger}

Petra Spröte,1,2 Axel A. Brakhage,1 and Michael J. Hynes2*

Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), and Department of Microbiology and Molecular Biology, Friedrich Schiller University Jena, Beutenbergstrasse 11a, 07745 Jena, Germany,1 Department of Genetics, University of Melbourne, Melbourne, Victoria 3010, Australia2

Received 26 November 2008/ Accepted 8 January 2009

Peroxisomal localization of the third enzyme of the penicillin biosynthesis pathway of Aspergillus nidulans, acyl-coenzyme A:IPN acyltransferase (IAT), is mediated by its atypical peroxisomal targeting signal 1 (PTS1). However, mislocalization of IAT by deletion of either its PTS1 or of genes encoding proteins involved in peroxisome formation or transport does not completely abolish penicillin biosynthesis. This is in contrast to the effects of IAT mislocalization in Penicillium chrysogenum.

* Corresponding author. Mailing address: Department of Genetics, University of Melbourne, Melbourne, Victoria 3010, Australia. Phone: 61 3 8344 6239. Fax: 61 3 8344 5139. E-mail: mjhynes{at}unimelb.edu.au

{triangledown} Published ahead of print on 16 January 2009.

{dagger} Supplemental material for this article may be found at http://ec.asm.org/.

Eukaryotic Cell, March 2009, p. 421-423, Vol. 8, No. 3
1535-9778/09/$08.00+0     doi:10.1128/EC.00374-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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