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A Ferroxidase Encoded by FOX1 Contributes to Iron Assimilation under Conditions of Poor Iron Nutrition in Chlamydomonas ^,

Jen-Chih Chen, Scott I. Hsieh, Janette Kropat, and Sabeeha S. Merchant^*

Department of Chemistry and Biochemistry, Box 951569, University of California—Los Angeles, Los Angeles, California 90095-1569

Received 26 December 2007/ Accepted 18 January 2008

When the abundance of the FOX1 gene product is reduced, Chlamydomonas cells grow poorly in iron-deficient medium, but not in iron-replete medium, suggesting that FOX1-dependent iron uptake is a high-affinity pathway. Alternative pathways for iron assimilation, such as those involving ZIP family transporters IRT1 and IRT2, may be operational.

Published ahead of print on 1 February 2008.

Supplemental material for this article may be found at http://ec.asm.org/.

Present address: Institute of Biotechology, National Taiwan University, Taipei 106, Taiwan.

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