Eukaryotic Cell
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Eukaryotic Cell, March 2008, p. 537-540, Vol. 7, No. 3
1535-9778/08/$08.00+0     doi:10.1128/EC.00448-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Toxoplasma gondii and Cryptosporidium parvum Lack Detectable DNA Cytosine Methylation{triangledown}

Mathieu Gissot,1 Sang-Woon Choi,2 Reid F. Thompson,3 John M. Greally,3 and Kami Kim1*

Departments of Medicine (Infectious Diseases) and Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York 10461,1 Jean Mayer USDA Human Nutrition Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111,2 Departments of Medicine (Hematology) and Molecular Genetics, Albert Einstein College of Medicine, Bronx, New York 104613

Received 9 December 2007/ Accepted 27 December 2007

Epigenetic factors play a role in the expression of virulence traits in Apicomplexa. Apicomplexan genomes encode putative DNA cytosine methylation enzymes. To assess the presence of cytosine methylation of Toxoplasma gondii and Cryptosporidium parvum DNA, we used mass spectrometry analysis and confirmed that these organisms lack detectable methylcytosine in their DNA.

* Corresponding author. Mailing address: Albert Einstein College of Medicine, Ullmann 1225, 1300 Morris Park Avenue, Bronx, NY 10461. Phone: (718) 430-2611. Fax: (718) 430-8968. E-mail: kkim{at}aecom.yu.edu

{triangledown} Published ahead of print on 4 January 2008.

Eukaryotic Cell, March 2008, p. 537-540, Vol. 7, No. 3
1535-9778/08/$08.00+0     doi:10.1128/EC.00448-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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