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 Previous Article

Eukaryotic Cell, February 2008, p. 425-428, Vol. 7, No. 2
1535-9778/08/$08.00+0     doi:10.1128/EC.00369-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Effect of Hydroxyurea on Procyclic Trypanosoma brucei: an Unconventional Mechanism for Achieving Synchronous Growth{triangledown}

Arnab Roy Chowdhury,{dagger} Zhixing Zhao,{dagger} and Paul T. Englund*

Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205

Received 8 October 2007/ Accepted 28 November 2007

Procyclic Trypanosoma brucei cells were synchronized with 0.2 mM hydroxyurea. The cells did not arrest at the G1/S boundary but proceeded through one round of replication and arrested near the end of S phase. The mitochondrial genome (kinetoplast DNA network) replicated, forming two progeny networks, but the repair of minicircle gaps was inhibited.

* Corresponding author. Mailing address: Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205. Phone: (410) 955-3790. Fax: (410) 955-7810. E-mail: penglund{at}jhmi.edu

{triangledown} Published ahead of print on 14 December 2007.

{dagger} Both authors contributed equally.

Eukaryotic Cell, February 2008, p. 425-428, Vol. 7, No. 2
1535-9778/08/$08.00+0     doi:10.1128/EC.00369-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Umeyama, T., Wang, C. C. (2008). Polo-Like Kinase Is Expressed in S/G2/M Phase and Associated with the Flagellum Attachment Zone in both Procyclic and Bloodstream Forms of Trypanosoma brucei. Eukaryot Cell 7: 1582-1590 [Abstract] [Full Text]  


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