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Eukaryotic Cell, September 2007, p. 1693-1696, Vol. 6, No. 9
1535-9778/07/$08.00+0     doi:10.1128/EC.00130-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Energy Metabolism of Bloodstream Form Trypanosoma theileri{triangledown}

Jaap J. van Hellemond,1,2 Aad Hoek,3 Paul Wichgers Schreur,1 Vladimir Chupin,4,{dagger} Suat Özdirekcan,4,{ddagger} Dirk Geysen,5 Koen W. A. van Grinsven,1 Ad P. Koets,6 Peter Van den Bossche,5 Stanny Geerts,5 and Aloysius G. M. Tielens1,2*

Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands,1 Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands,2 Division of Immunology, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands,3 Department of Biochemistry of Membranes, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH Utrecht, The Netherlands,4 Institute of Tropical Medicine, Nationalestraat 155, 2000 Antwerpen, Belgium,5 Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands6

Received 19 April 2007/ Accepted 10 July 2007

Bloodstream form Trypanosoma theileri degrades glucose to acetate (47%) and succinate (45%) and, therefore, does not solely rely on glycolysis for ATP production. This trypanosomatid does not use amino acids for energy metabolism. These results refute the prevailing hypothesis that substrate availability determines the type of energy metabolism of trypanosomatids.

* Corresponding author. Mailing address: Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80176, 3508 TD Utrecht, The Netherlands. Phone: 31 30 2535380. Fax: 31 30 2535492. E-mail: a.g.m.tielens{at}vet.uu.nl

{triangledown} Published ahead of print on 20 July 2007.

{dagger} Present address: Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 16/10 Miklukho Maklaya Str., Moscow, 117997 Russia.

{ddagger} Present address: Department of NMR spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH Utrecht, The Netherlands.

Eukaryotic Cell, September 2007, p. 1693-1696, Vol. 6, No. 9
1535-9778/07/$08.00+0     doi:10.1128/EC.00130-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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