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Transgenic Leishmania Model for Delta-Aminolevulinate-Inducible Monospecific Uroporphyria: Cytolytic Phototoxicity Initiated by Singlet Oxygen-Mediated Inactivation of Proteins and Its Ablation by Endosomal Mobilization of Cytosolic Uroporphyrin
Eukaryotic Cell Dutta et al. 7: 1146

Supplemental material

Files in this Data Supplement:

  • Supplemental file 1 - Supplemental legends.
    MS Word document, 39K.
  • Supplemental file 2 - Uroporphyria and its phototoxic phenotype of flagellar immobilization as a function of exogenous ALA concentrations.
    TIFF image, 651K.
  • Supplemental file 3 - Kinetics of ALA-induced uroporphyrinogenesis of Leishmania transfectants cloned after six cycles of ALA-induced uroporphyria followed by UV exposure for cytolysis.
    TIFF image, 966K.



This Article
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