EC Accepts, published online ahead of print on 19 June 2009

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Eukaryotic Cell doi:10.1128/EC.00091-09
Copyright (c) 2009, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved.

Adaptations in the glucose metabolism of procyclic Trypanosoma brucei isolated from tsetse flies and during differentiation of bloodstream forms

Koen W.A. van Grinsven, Jan Van Den Abbeele, Peter Van den Bossche, Jaap J. van Hellemond, and Aloysius G.M. Tielens^*

Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands; Department of Parasitology, Unit of Entomology, Institute of Tropical Medicine Antwerp, B-2000 Antwerp, Belgium; Department of Animal Health, Institute of Tropical Medicine Antwerp, B-2000 Antwerp, Belgium; Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, Onderstepoort, South Africa; and Department of Medical Microbiology & Infectious Diseases, ErasmusMC University Medical Center, 3015 GD Rotterdam, The Netherlands

^* To whom correspondence should be addressed. Email: a.tielens{at}erasmusmc.nl.

Procyclic forms of Trypanosoma brucei isolated from midguts of infected tsetse flies, or freshly transformed from a strain that is close to field isolates, do not use a complete Krebs cycle. Furthermore, short-stumpy bloodstream forms produce acetate and are apparently metabolically pre-adapted to adequate functioning in the tsetse fly.