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Eukaryotic Cell, February 2009, p. 251-256, Vol. 8, No. 2
1535-9778/09/$08.00+0     doi:10.1128/EC.00320-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The White Cell Response to Pheromone Is a General Characteristic of Candida albicans Strains{triangledown} ,{dagger}

Nidhi Sahni, Song Yi, Claude Pujol, and David R. Soll*

Department of Biology, The University of Iowa, Iowa City, Iowa 52242

Received 19 September 2008/ Accepted 2 December 2008

For Candida albicans, evidence has suggested that the mating pheromones activate not only the mating response in mating-competent opaque cells but also a unique response in mating-incompetent white cells that includes increased cohesion and adhesion, enhanced biofilm formation, and expression of select mating-related and white cell-specific genes. On the basis of a recent microarray analysis comparing changes in the global expression patterns of white cells in two strains in response to {alpha}-pheromone, however, skepticism concerning the validity and generality of the white cell response has been voiced. Here, we present evidence that the response occurs in all tested media (Lee's, RPMI, SpiderM, yeast extract-peptone-dextrose, and a synthetic medium) and in all of the 27 tested strains, including a/a and {alpha}/{alpha} strains, derivatives of the common laboratory strain SC5314, and representatives from all of the five major clades. The white cell response to pheromone is therefore a general characteristic of MTL-homozygous strains of C. albicans.

* Corresponding author. Mailing address: Department of Biology, 302 BBE, the University of Iowa, Iowa City, IA 52242. Phone: (319) 335-1117. Fax: (319) 335-2772. E-mail: david-soll{at}uiowa.edu

{triangledown} Published ahead of print on 12 December 2008.

{dagger} Supplemental material for this article may be found at http://ec.asm.org/.

Eukaryotic Cell, February 2009, p. 251-256, Vol. 8, No. 2
1535-9778/09/$08.00+0     doi:10.1128/EC.00320-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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