This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cockell, M. M.
Right arrow Articles by Simanis, V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cockell, M. M.
Right arrow Articles by Simanis, V.

 Previous Article  |  Next Article 

Eukaryotic Cell, February 2009, p. 207-216, Vol. 8, No. 2
1535-9778/09/$08.00+0     doi:10.1128/EC.00174-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Functional Differentiation of tbf1 Orthologues in Fission and Budding Yeasts{triangledown} ,{dagger}

Moira M. Cockell,1,{ddagger} Libera Lo Presti,1 Lorenzo Cerutti,2 Elena Cano Del Rosario,3 Philippe M. Hauser,1 and Viesturs Simanis3*

Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland,1 Swiss Institute of Bioinformatics, Lausanne, Switzerland,2 Faculty of Life Sciences, EPFL, and Swiss Institute for Experimental Cancer Research, Epalinges, Switzerland3

Received 28 May 2008/ Accepted 26 November 2008

In Saccharomyces cerevisiae, TBF1, an essential gene, influences telomere function but also has other roles in the global regulation of transcription. We have identified a new member of the tbf1 gene family in the mammalian pathogen Pneumocystis carinii. We demonstrate by transspecies complementation that its ectopic expression can provide the essential functions of Schizosaccharomyces pombe tbf1 but that there is no rescue between fission and budding yeast orthologues. Our findings indicate that an essential function of this family of proteins has diverged in the budding and fission yeasts and suggest that effects on telomere length or structure are not the primary cause of inviability in S. pombe tbf1 null strains.

* Corresponding author. Mailing address: Faculty of Life Sciences, EPFL, and Swiss Institute for Experimental Cancer Research (ISREC), Epalinges, Switzerland. Phone: 41 021 6925888. Fax: 41 021 6926533. E-mail: viesturs.simanis{at}epfl.ch

{triangledown} Published ahead of print on 12 December 2008.

{dagger} Supplemental material for this article may be found at http://ec.asm.org/.

{ddagger} Present address: World Knowledge Dialogue, Lausanne, Switzerland.

Eukaryotic Cell, February 2009, p. 207-216, Vol. 8, No. 2
1535-9778/09/$08.00+0     doi:10.1128/EC.00174-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»