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Eukaryotic Cell, November 2009, p. 1808-1811, Vol. 8, No. 11
1535-9778/09/$08.00+0     doi:10.1128/EC.00217-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Neurofibromin Homologs Ira1 and Ira2 Affect Glycerophosphoinositol Production and Transport in Saccharomyces cerevisiae{triangledown}

Andrew C. Bishop,{dagger} Beth A. Surlow,{dagger} Puneet Anand,{ddagger} Katherine Hofer,§ Matthew Henkel, and Jana Patton-Vogt*

Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282

Received 27 July 2009/ Accepted 24 August 2009

Saccharomyces cerevisiae produces extracellular glycerophosphoinositol through phospholipase-mediated turnover of phosphatidylinositol and transports glycerophosphoinositol into the cell upon nutrient limitation. A screening identified the RAS GTPase-activating proteins Ira1 and Ira2 as required for utilization of glycerophosphoinositol as the sole phosphate source, but the RAS/cyclic AMP pathway does not appear to be involved in the growth phenotype. Ira1 and Ira2 affect both the production and transport of glycerophosphoinositol.

* Corresponding author. Mailing address: Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282. Phone: (412) 396-1053. Fax: (412) 396-5907. E-mail: pattonvogt{at}duq.edu

{triangledown} Published ahead of print on 28 August 2009.

{dagger} A. C. Bishop and B. A. Surlow contributed equally to this work.

{ddagger} Present address: Department of Biochemistry, Duke University Medical Center, Durham, NC 27710.

§ Present address: Department of Biological Sciences, University of Buffalo, Buffalo, NY 14260.

Eukaryotic Cell, November 2009, p. 1808-1811, Vol. 8, No. 11
1535-9778/09/$08.00+0     doi:10.1128/EC.00217-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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