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Eukaryotic Cell, September 2008, p. 1611-1615, Vol. 7, No. 9
1535-9778/08/$08.00+0     doi:10.1128/EC.00458-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

β1,2-Xylosyltransferase Cxt1p Is Solely Responsible for Xylose Incorporation into Cryptococcus neoformans Glycosphingolipids{triangledown}

Sherry A. Castle,1 Elizabeth A. Owuor,1 Stephanie H. Thompson,1 Michelle R. Garnsey,1 J. Stacey Klutts,2,3,{dagger} Tamara L. Doering,2 and Steven B. Levery1*

Department of Chemistry, University of New Hampshire, G229 Parsons Hall, Durham, New Hampshire 03824-3598,1 Departments of Molecular Microbiology,2 Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 631103

Received 20 December 2007/ Accepted 22 July 2008

The Man{alpha}1,3(Xylβ1,2)Man{alpha} structural motif is common to both capsular polysaccharides of Cryptococcus neoformans and to cryptococcal glycosphingolipids. Comparative analysis of glycosphingolipid structural profiles in wild-type and mutant strains showed that the Xylβ1,2-transferase (Cxt1p) that participates in capsular polysaccharide biosynthesis is also the sole transferase responsible for adding xylose to C. neoformans glycosphingolipids.

* Corresponding author. Present address: Department of Molecular and Cellular Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen, 2200 N, Denmark. Phone: 45 3532 7779. Fax: 45 3536 7980. E-mail: levery{at}imbg.ku.dk

{triangledown} Published ahead of print on 1 August 2008.

{dagger} Present address: University of Iowa Carver College of Medicine, Iowa City, IA 52246.

Eukaryotic Cell, September 2008, p. 1611-1615, Vol. 7, No. 9
1535-9778/08/$08.00+0     doi:10.1128/EC.00458-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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