This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental material
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cornillon, S.
Right arrow Articles by Cosson, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cornillon, S.
Right arrow Articles by Cosson, P.

 Previous Article  |  Next Article 

Eukaryotic Cell, September 2008, p. 1600-1605, Vol. 7, No. 9
1535-9778/08/$08.00+0     doi:10.1128/EC.00155-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Involvement of Sib Proteins in the Regulation of Cellular Adhesion in Dictyostelium discoideum{triangledown} ,{dagger}

Sophie Cornillon, Romain Froquet, and Pierre Cosson*

Geneva Faculty of Medicine, Cell Physiology and Metabolism Department, Centre Médical Universitaire, 1 Rue Michel Servet, 1211 Geneva 4, Switzerland

Received 5 May 2008/ Accepted 21 July 2008

Molecular mechanisms ensuring cellular adhesion have been studied in detail in Dictyostelium amoebae, but little is known about the regulation of cellular adhesion in these cells. Here, we show that cellular adhesion is regulated in Dictyostelium, notably by the concentration of a cellular secreted factor accumulating in the medium. This constitutes a quorum-sensing mechanism allowing coordinated regulation of cellular adhesion in a Dictyostelium population. In order to understand the mechanism underlying this regulation, we analyzed the expression of recently identified Dictyostelium adhesion molecules (Sib proteins) that present features also found in mammalian integrins. sibA and sibC are both expressed in vegetative Dictyostelium cells, but the expression of sibC is repressed strongly in conditions where cellular adhesion decreases. Analysis of sibA and sibC mutant cells further suggests that variations in the expression levels of sibC account largely for changes in cellular adhesion in response to environmental cues.

* Corresponding author. Mailing address: Geneva Faculty of Medicine, Cell Physiology and Metabolism Department, Centre Médical Universitaire, 1 Rue Michel Servet, 1211 Geneva 4, Switzerland. Phone: (41) 22 379 5293. Fax: (41) 22 379 5338. E-mail: Pierre.Cosson{at}medecine.unige.ch

{triangledown} Published ahead of print on 1 August 2008.

{dagger} Supplemental material for this article may be found at http://ec.asm.org/.

Eukaryotic Cell, September 2008, p. 1600-1605, Vol. 7, No. 9
1535-9778/08/$08.00+0     doi:10.1128/EC.00155-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Weijer, C. J. (2009). Collective cell migration in development. J. Cell Sci. 122: 3215-3223 [Abstract] [Full Text]  
  • Engler, A. J., Humbert, P. O., Wehrle-Haller, B., Weaver, V. M. (2009). Multiscale Modeling of Form and Function. Science 324: 208-212 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»