Eukaryotic Cell
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Eukaryotic Cell, May 2008, p. 814-825, Vol. 7, No. 5
1535-9778/08/$08.00+0     doi:10.1128/EC.00011-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

High Resistance to Oxidative Stress in the Fungal Pathogen Candida glabrata Is Mediated by a Single Catalase, Cta1p, and Is Controlled by the Transcription Factors Yap1p, Skn7p, Msn2p, and Msn4p{triangledown}

Mayra Cuéllar-Cruz,{dagger} Marcela Briones-Martin-del-Campo,{dagger} Israel Cañas-Villamar, Javier Montalvo-Arredondo, Lina Riego-Ruiz, Irene Castaño, and Alejandro De Las Peñas*

División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México

Received 7 January 2008/ Accepted 18 March 2008

We characterized the oxidative stress response of Candida glabrata to better understand the virulence of this fungal pathogen. C. glabrata could withstand higher concentrations of H2O2 than Saccharomyces cerevisiae and even Candida albicans. Stationary-phase cells were extremely resistant to oxidative stress, and this resistance was dependent on the concerted roles of stress-related transcription factors Yap1p, Skn7p, and Msn4p. We showed that growing cells of C. glabrata were able to adapt to high levels of H2O2 and that this adaptive response was dependent on Yap1p and Skn7p and partially on the general stress transcription factors Msn2p and Msn4p. C. glabrata has a single catalase gene, CTA1, which was absolutely required for resistance to H2O2 in vitro. However, in a mouse model of systemic infection, a strain lacking CTA1 showed no effect on virulence.

* Corresponding author. Mailing address: Camino a la Presa San José 2055, División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, San Luis Potosí 78216, México. Phone: (52) 444 8342000. Fax: (52) 444 8342010. E-mail: cano{at}ipicyt.edu.mx

{triangledown} Published ahead of print on 28 March 2008.

{dagger} These authors contributed equally.

Eukaryotic Cell, May 2008, p. 814-825, Vol. 7, No. 5
1535-9778/08/$08.00+0     doi:10.1128/EC.00011-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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