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Eukaryotic Cell, March 2008, p. 546-549, Vol. 7, No. 3
1535-9778/08/$08.00+0     doi:10.1128/EC.00437-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Regulation of Cryptococcus neoformans Capsule Size Is Mediated at the Polymer Level{triangledown}

Aki Yoneda and Tamara L. Doering*

Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110

Received 30 November 2007/ Accepted 17 December 2007

The fungal pathogen Cryptococcus neoformans regulates its polysaccharide capsule depending on environmental stimuli. To investigate whether capsule polymers change under different growth conditions, we analyzed shed capsules at physiological concentrations without physical perturbation. Our results indicate that regulation of capsule size is mediated at the level of individual polysaccharide molecules.

* Corresponding author. Mailing address: Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110. Phone: (314) 747-5597. Fax: (314) 362-1232. E-mail: doering{at}borcim.wustl.edu

{triangledown} Published ahead of print on 21 December 2007.

Eukaryotic Cell, March 2008, p. 546-549, Vol. 7, No. 3
1535-9778/08/$08.00+0     doi:10.1128/EC.00437-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Frases, S., Pontes, B., Nimrichter, L., Viana, N. B., Rodrigues, M. L., Casadevall, A. (2009). Capsule of Cryptococcus neoformans grows by enlargement of polysaccharide molecules. Proc. Natl. Acad. Sci. USA 106: 1228-1233 [Abstract] [Full Text]  


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