Eukaryotic Cell
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
EC.00369-07v1
7/2/425    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Chowdhury, A. R.
Right arrow Articles by Englund, P. T.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chowdhury, A. R.
Right arrow Articles by Englund, P. T.
Eukaryotic Cell, February 2008, p. 425-428, Vol. 7, No. 2
1535-9778/08/$08.00+0     doi:10.1128/EC.00369-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Effect of Hydroxyurea on Procyclic Trypanosoma brucei: an Unconventional Mechanism for Achieving Synchronous Growth{triangledown}

Arnab Roy Chowdhury,{dagger} Zhixing Zhao,{dagger} and Paul T. Englund*

Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205

Received 8 October 2007/ Accepted 28 November 2007

Procyclic Trypanosoma brucei cells were synchronized with 0.2 mM hydroxyurea. The cells did not arrest at the G1/S boundary but proceeded through one round of replication and arrested near the end of S phase. The mitochondrial genome (kinetoplast DNA network) replicated, forming two progeny networks, but the repair of minicircle gaps was inhibited.

* Corresponding author. Mailing address: Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205. Phone: (410) 955-3790. Fax: (410) 955-7810. E-mail: penglund{at}jhmi.edu

{triangledown} Published ahead of print on 14 December 2007.

{dagger} Both authors contributed equally.

Eukaryotic Cell, February 2008, p. 425-428, Vol. 7, No. 2
1535-9778/08/$08.00+0     doi:10.1128/EC.00369-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Appl. Environ. Microbiol. Infect. Immun. J. Bacteriol.
Mol. Cell Biol. Microbiol. Mol. Biol. Rev. ALL ASM JOURNALS
Copyright © 2008 by the American Society for Microbiology.